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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Updated: Nov 16, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
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Systemic Therapy for Mutation-Driven NSCLC.

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This summary is machine-generated.

New therapies target specific mutations in nonsmall cell lung cancer (NSCLC), improving patient outcomes. This review covers systemic treatments and their safety when combined with radiation therapy for NSCLC.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Medical Therapeutics

Background:

  • Lung cancer remains a leading cause of cancer mortality globally.
  • Nonsmall cell lung cancer (NSCLC) historically presents a poor prognosis for patients.
  • Advances in understanding oncogenic drivers have enabled targeted therapies.

Purpose of the Study:

  • To review current systemic therapy options for mutation-driven NSCLC.
  • To discuss the safety of combining these therapies with radiation therapy.

Main Methods:

  • Literature review of systemic therapy options for NSCLC.
  • Analysis of safety data for combined modality treatments.

Main Results:

  • Several effective first-line therapies are available for specific molecular alterations in NSCLC.
  • Data on the safety of combining systemic therapies with radiation therapy is emerging.

Conclusions:

  • Targeted therapies have significantly improved treatment paradigms for NSCLC.
  • Careful consideration of safety is required when integrating systemic treatments with radiation therapy.