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Fractional Mathematical Oncology: On the potential of non-integer order calculus applied to interdisciplinary models
Carlos A Valentim1, José A Rabi1, Sergio A David1
1Department of Biosystems Engineering, University of São Paulo, Pirassununga Campus, Brazil.
Abstract:
Mathematical Oncology investigates cancer-related phenomena through mathematical models as comprehensive as possible. Accordingly, an interdisciplinary approach involving concepts from biology to materials science can provide a deeper understanding of biological systems pertaining the disease. In this context, fractional calculus (also referred to as non-integer order) is a branch in mathematical analysis whose tools can describe complex phenomena comprising different time and space scales. Fractional-order models may allow a better description and understanding of oncological particularities, potentially contributing to decision-making in areas of interest such as tumor evolution, early diagnosis techniques and personalized treatment therapies. By following a phenomenological (i.e. mechanistic) approach, the present study surveys and explores different aspects of Fractional Mathematical Oncology, reviewing and discussing recent developments in view of their prospective applications.
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