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Updated: Nov 16, 2025
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
Published on: June 15, 2018
miR-29 family: A potential therapeutic target for cardiovascular disease
Meng-Nan Liu1, Gang Luo2, Wan-Jiao Gao3
1Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China; National Traditional Chinese Medicine Clinical Research Base and Department of Cardiovascular Medicine, Hospital (T.C.M) Affiliated to Southwest Medical University, Luzhou, Sichuan, China.
Insights
The miR-29 family is crucial in cardiovascular diseases (CVD), impacting heart failure, myocardial fibrosis, and infarction. This review highlights miR-29
Area of Science:
- Biomedical Science
- Molecular Biology
- Cardiology
Background:
- Cardiovascular disease (CVD) is a leading global cause of mortality.
- MicroRNAs (miRNAs) are implicated in the pathogenesis of CVD.
- The miR-29 family is a key regulator in cardiovascular health.
Purpose of the Study:
- To comprehensively review the role of the miR-29 family in cardiovascular disease.
- To explore miR-29's involvement in myocardial fibrosis and atherosclerosis.
- To assess miR-29 as a potential biomarker for CVD prevention, treatment, and prognosis.
Main Methods:
- Literature review of recent studies on miR-29 and CVD.
- Analysis of miR-29's regulatory mechanisms in cardiovascular pathogenesis.
- Synthesis of evidence regarding miR-29's clinical implications.
Main Results:
- miR-29 family plays a significant role in maintaining arterial integrity.
- miR-29 is critically involved in regulating atherosclerosis and myocardial fibrosis.
- The miR-29 family is intrinsically linked to heart failure, myocardial fibrosis, and myocardial infarction.
Conclusions:
- miR-29 is a key player in the development and progression of cardiovascular diseases.
- miR-29 demonstrates potential as a diagnostic and prognostic biomarker for CVD.
- Targeting miR-29 may offer novel therapeutic strategies for cardiovascular conditions.
Abstract:
Cardiovascular disease (CVD), including heart failure, myocardial fibrosis and myocardial infarction, etc, remains one of the leading causes of mortality worldwide. Evidence shows that miRNA plays an important role in the pathogenesis of CVD. miR-29 family is one of miRNA, and over the past decades, many studies have demonstrated that miR-29 is involved in maintaining the integrity of arteries and in the regulation of atherosclerosis, especially in the process of myocardial fibrosis. Besides, heart failure, myocardial fibrosis and myocardial infarction are inseparable from the regulatory role of miR-29. Here, we comprehensively review recent studies regarding miR-29 and CVD, illustrate the possibility of miR-29 as a potential marker for prevention, treatment and prognostic observation.
