Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Factitious transient neonatal hyperthyrotropinemia.

N Jospe1, G D Berkovitz, L E Corcoran

  • 1Division of Pediatric Endocrinology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205.

Journal of Endocrinological Investigation
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative.

Diabetes/metabolism research and reviews·2011
Same author

Immunology of Diabetes Society T-Cell Workshop: HLA class II tetramer-directed epitope validation initiative.

Diabetes/metabolism research and reviews·2011
Same author

Attitudes of adult 46, XY intersex persons to clinical management policies.

The Journal of urology·2004
Same author

Congenital micropenis: long-term medical, surgical and psychosexual follow-up of individuals raised male or female.

Hormone research·2002
Same author

Absence of mutations involving the LIM homeobox domain gene LHX9 in 46,XY gonadal agenesis and dysgenesis.

The Journal of clinical endocrinology and metabolism·2001
Same author

Third-year medical student survey of office preceptorships during the pediatric clerkship.

Archives of pediatrics & adolescent medicine·2001
Same journal

lncRNA PANDAR predicts adverse pregnancy outcomes and reflects hyperglycemia-associated cellular stress in gestational diabetes mellitus.

Journal of endocrinological investigation·2026
Same journal

Correction: Early in, early out: reproductive lifespan timing and cardiometabolic risk in women.

Journal of endocrinological investigation·2026
Same journal

Adult mice are more susceptible to high-fat diet-induced visceral adiposity and insulin resistance than juvenile mice.

Journal of endocrinological investigation·2026
Same journal

Lactobacillus gasseri alleviates type 2 diabetes via modulation of gut microbiota-host metabolic networks.

Journal of endocrinological investigation·2026
Same journal

Rare causes of exogenous Cushing's Syndrome: a challenge for endocrinologists.

Journal of endocrinological investigation·2026
Same journal

Phase angle and triglyceride-glucose index as biomarkers of glycemic control, body composition and cardiovascular risk in adolescents with type 1 diabetes: a cross-sectional study.

Journal of endocrinological investigation·2026
See all related articles

A mother's sarcoidosis caused abnormal thyroid-stimulating hormone (TSH) levels in her infant due to interfering immunoglobulin G (IgG). This interference affected neonatal screening tests, highlighting potential diagnostic challenges.

Area of Science:

  • Endocrinology
  • Immunology
  • Neonatal Screening

Background:

  • Neonatal screening programs are crucial for early detection of congenital hypothyroidism.
  • Thyroid-stimulating hormone (TSH) assays are standard for neonatal thyroid function testing.
  • Maternal health conditions can potentially influence neonatal screening results.

Observation:

  • An infant presented with elevated TSH levels detected by one specific neonatal screening laboratory.
  • The infant's TSH levels normalized spontaneously by six months of age.
  • The infant's mother, with a history of sarcoidosis, exhibited factitious hyperthyrotropinemia in the same laboratory.

Findings:

  • Gel chromatography and ammonium sulfate precipitation identified an immunoglobulin G (IgG) as the cause of factitious hyperthyrotropinemia in the maternal serum.

Related Experiment Videos

  • Treatment of maternal serum with polyethylene glycol normalized TSH levels, confirming the immunoglobulin interference.
  • Standard immunological tests including protein electrophoresis and immunofixation electrophoresis were normal, suggesting a specific subclass of IgG was involved.

    • Implications:

    • This case highlights a potential source of false-positive neonatal TSH screening results.
    • Sarcoidosis may be associated with specific IgG subclasses that interfere with certain TSH immunoassays.
    • Further investigation into assay interference by specific immunoglobulin subclasses is warranted for accurate neonatal thyroid screening.