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Mid-term outcomes of coronary artery bypass grafting in patients with mild left ventricular systolic dysfunction: a

Hang Zhang1, Ronghui Shi2, Wei Qin1

  • 1Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Interactive Cardiovascular and Thoracic Surgery
|February 21, 2021
PubMed

Insights

Patients with mild left ventricular systolic dysfunction (LVSD) undergoing coronary artery bypass grafting (CABG) face worse mid-term outcomes, including increased risks of all-cause mortality and heart failure.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Cardiovascular Research

Background:

  • Left ventricular systolic dysfunction (LVSD) is a known risk factor for adverse events after coronary artery bypass grafting (CABG).
  • The specific mid-term prognosis for patients with mild LVSD post-CABG remains incompletely understood.

Purpose of the Study:

  • To evaluate the mid-term clinical outcomes of patients with mild LVSD following CABG.
  • To compare outcomes between patients with and without mild LVSD after undergoing CABG.

Main Methods:

  • A multicentre cohort study involving propensity score matching of 581 patient pairs.
  • Patients were categorized into normal left ventricular systolic function (LVEF ≥53%) and mild LVSD (LVEF >40%/<53%).
  • Primary outcomes included all-cause mortality and cardiovascular death; secondary outcomes comprised heart failure, myocardial infarction, repeat revascularization, and major adverse events.

Main Results:

  • No significant difference in in-hospital mortality between groups.
  • Mild LVSD was associated with significantly higher rates of all-cause mortality (HR 0.59), cardiovascular death (HR 0.55), heart failure (HR 0.60), and major adverse events (HR 0.66) over 7 years.
  • No significant differences were observed in myocardial infarction or repeat revascularization rates.

Conclusions:

  • Mild LVSD is linked to a poorer mid-term prognosis in patients who have undergone CABG.
  • These findings highlight the importance of considering LVSD severity in risk stratification and management strategies for CABG patients.
Abstract

Keywords:
Coronary artery bypass graftingLeft ventricular ejection fractionMild left ventricular systolic dysfunctionPrognosis

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