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COVID-19 outcomes in patients with familial Mediterranean fever: a retrospective cohort study

Serdar Can Güven1, Abdulsamet Erden2, Özlem Karakaş2

  • 1Clinic of Rheumatology, Ministry of Health Ankara City Hospital, Bilkent, Çankaya, Ankara, Turkey. drserdarguven@gmail.com.

Rheumatology International
|February 21, 2021
PubMed

Insights

Familial Mediterranean fever (FMF) patients with COVID-19 showed increased hospitalization rates, particularly those with comorbidities or on IL-1 inhibitor treatment. One patient died, highlighting the need for careful monitoring in this vulnerable population.

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Genetics

Background:

  • Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder.
  • Understanding COVID-19's impact on FMF patients is crucial for clinical management.

Purpose of the Study:

  • To investigate the clinical course of coronavirus disease 2019 (COVID-19) in patients with FMF.
  • To assess mortality, hospitalization, and intensive care unit (ICU) admission rates in this cohort.

Main Methods:

  • Retrospective cohort study of 496 FMF patients.
  • Analysis of SARS-CoV-2 PCR positive cases, treatment, comorbidities, and hospitalization data.

Main Results:

  • 34 out of 496 FMF patients tested positive for SARS-CoV-2.
  • Hospitalization occurred in 23.9% of COVID-19 positive FMF patients, with one fatality (2.9%).
  • Hospitalized patients showed higher rates of comorbidities and IL-1 inhibitor use.

Conclusions:

  • FMF patients hospitalized for COVID-19 had increased comorbid conditions and IL-1 inhibitor usage.
  • These findings suggest a need for vigilant monitoring of FMF patients during the COVID-19 pandemic.

Keywords:
CoronavirusFamilialFeverMediterraneanOutcome

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