Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
Pigmentation01:19

Pigmentation

3.7K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
3.7K
Burn Injuries01:22

Burn Injuries

3.4K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
3.4K
Mutations01:35

Mutations

41.9K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
41.9K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.0K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.0K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

4.4K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HAND-Q: A global normative data sample of 1373 participants.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026
Same author

Breast sensibility in a breast cancer population - Reference data for clinical practice.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2025
Same author

Rhabdomyolysis induced by darolutamide and rosuvastatin.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2025
Same author

Comprehensive Assessment of Specific Patient-Reported Outcome Measures for Hand and Wrist Conditions in Adults: A Scoping Review.

JPRAS open·2025
Same author

Breast implant illness revisited: A cohort study of health symptoms in women with implant-based reconstruction.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2025
Same author

Health symptoms and cosmetic silicone breast implants: A retrospective cohort study.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2024

Related Experiment Video

Updated: Nov 16, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.5K

Sun Protection Behavior Following Skin Cancer Resection and Reconstruction.

I J Veldhuizen1,2,3, E Schroen1, E H Lee2

  • 1Department of Plastic and Reconstructive Surgery, Catharina Hospital, Eindhoven, the Netherlands.

Journal of Cancer Education : the Official Journal of the American Association for Cancer Education
|February 21, 2021
PubMed
Summary

Patients undergoing Mohs micrographic surgery (MMS) showed improved sun protection behaviors post-procedure. Targeted counseling may further enhance these behaviors, especially for those with prior skin cancer or defects on the ear/scalp.

Keywords:
Patient reported outcomeSkin cancerSun protectionUltraviolet radiationWound healing

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

9.2K
Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

1.4K

Related Experiment Videos

Last Updated: Nov 16, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.5K
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

9.2K
Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

1.4K

Area of Science:

  • Dermatology
  • Surgical Oncology
  • Public Health

Background:

  • Ultraviolet radiation (UVR) exposure increases nonmelanoma skin cancer risk and negatively impacts cutaneous surgery outcomes.
  • Delayed wound healing, scar hyperpigmentation, and increased secondary skin cancer incidence are complications linked to UVR exposure post-surgery.
  • Modifying sun protection behavior is crucial for mitigating these risks.

Purpose of the Study:

  • To evaluate changes in sun protective behavior among patients following Mohs micrographic surgery (MMS).
  • To identify patient subgroups that may benefit from targeted interventions to improve sun protection.

Main Methods:

  • A prospective study involving 125 patients undergoing MMS between December 2017 and November 2019.
  • Patients completed the FACE-Q Skin Cancer - Sun Protection Behavior checklist pre-operatively, and at 3 months and 1 year post-surgery.
  • Statistical analysis compared pre- and post-operative behavior scores, and analyzed differences based on patient history and defect location.

Main Results:

  • Sun protective behaviors significantly increased at all post-operative time points (p < 0.001).
  • Patients with a history of facial skin cancer showed a greater increase in sun protection compared to those without (p = 0.04).
  • Patients with defects on the ear or scalp exhibited a lesser increase in sun protection compared to those with facial defects (p = 0.02).

Conclusions:

  • Mohs micrographic surgery prompts an increase in sun protection behaviors over time.
  • Further improvements in sun protection are possible through targeted counseling.
  • Interventions should focus on patients with a history of skin cancer and those with defects in less conspicuous areas like the ear or scalp.