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Pregnancy-induced hypertension and retinopathy of prematurity: a meta-analysis

Ge Ge1, Yun Zhang1, Meixia Zhang1

  • 1Macular Disease Research Laboratory, Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, China.

Acta Ophthalmologica
|February 21, 2021
PubMed

Insights

This meta-analysis found no significant association between pregnancy-induced hypertension (PIH) and retinopathy of prematurity (ROP). Further research is needed to understand the effect of maternal PIH on ROP and its prevention.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Maternal-Fetal Medicine

Background:

  • Retinopathy of prematurity (ROP) is a leading cause of childhood blindness.
  • ROP development involves complex antenatal and neonatal factors.
  • Pregnancy-induced hypertension (PIH) is a potential contributing factor under investigation.

Purpose of the Study:

  • To investigate the association between pregnancy-induced hypertension (PIH) and retinopathy of prematurity (ROP).
  • To summarize existing evidence through a meta-analysis.
  • To clarify the role of PIH in ROP development.

Main Methods:

  • Comprehensive literature search of major databases (PubMed, EMBASE, Web of Science, EBSCO, SCOPUS) up to April 2020.
  • Inclusion of case-control and cohort studies examining the PIH-ROP relationship.
  • Meta-analysis of data from 29 selected studies.

Main Results:

  • No significant association was found between PIH and ROP in case-control studies (OR 0.91, 95%CI 0.59-1.40).
  • No significant association was found between PIH and ROP in cohort studies (OR 1.32, 95%CI 0.89-1.98).
  • Similar inconclusive results were observed for pre-eclampsia and ROP.

Conclusions:

  • This meta-analysis did not reveal a consistent association between PIH and ROP.
  • The current evidence remains inconclusive regarding the effect of maternal PIH on ROP.
  • Further high-quality studies are required to establish a definitive conclusion and inform ROP prevention strategies.
Abstract

Keywords:
meta-analysispre-eclampsiapregnancy-induced hypertensionretinal disorderretinopathy of prematurity

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