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Updated: Nov 16, 2025

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
A systematic review and meta-analysis on cognitive frailty in community-dwelling older adults: risk and associated
Izabela Pereira Vatanabe1, Renata Valle Pedroso1, Ramon Handerson Gomes Teles2
1Department of Gerontology, Universidade Federal de São Carlos, Monjolinho, São Carlos, Brazil.
Objectives:
To identify which factors are associated with cognitive frailty (CF), as well as the impact of CF on the incidence of dementia and mortality.
Methods:
A systematic review with meta-analysis was carried out using papers that enrolled a total of 75,379 participants and were published up to January 2020.
Results:
Of the 558 identified records, 28 studies met the inclusion criteria and were included in the review. The meta-analysis of cross-sectional studies showed that CF has a significant association of having an older age and a history of falls. In longitudinal studies, the analysis showed a significant increase in risk of mortality and dementia for those with CF.
Discussion:
This is the first systematic review and meta-analysis on CF, which addressed a wide variety of factors associated with the theme and which pointed out some as a potential target for prevention or management with different interventions or treatments, showing the clinical importance of its identification in the most vulnerable and susceptible groups.
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