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Updated: Nov 16, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
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COVID-19 lungs in post-mortem computed tomography.

I Kniep1, A Heinemann1, C Edler1

  • 1Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Butenfeld 34, 22529 Hamburg, Germany.

Rechtsmedizin (Berlin, Germany)
|February 22, 2021
PubMed
Summary
This summary is machine-generated.

Post-mortem computed tomography (PMCT) aids in identifying COVID-19 pneumonia findings in deceased individuals. Typical PMCT patterns for SARS-CoV-2 pneumonia were frequently observed, assisting in death classification.

Keywords:
ConsolidationGround glass opacitiesHypostasisPulmonary manifestationSARS-CoV-2

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Area of Science:

  • Forensic Radiology
  • Pathology
  • Infectious Diseases

Background:

  • Post-mortem computed tomography (PMCT) is a valuable, noninvasive tool for diagnosing pulmonary conditions in deceased individuals.
  • While computed tomography (CT) is sensitive for pneumonia in living patients, it lacks specificity for COVID-19 pneumonia, often requiring PCR confirmation.
  • Characteristic CT findings for viral pneumonia, including ground glass opacities (GGO) and consolidations, are associated with SARS-CoV-2 infections.

Purpose of the Study:

  • To evaluate the utility of PMCT in identifying pulmonary findings in deceased individuals with COVID-19 pneumonia.
  • To assess the frequency and characteristics of PMCT findings in deaths attributed to SARS-CoV-2.
  • To determine if PMCT findings contribute to the classification of COVID-19 as the cause of death.

Main Methods:

  • Analysis of a consecutive autopsy series of SARS-CoV-2 deaths from Hamburg, Germany.
  • Review of PMCT scans to identify pulmonary findings.
  • Correlation of PMCT findings with clinical and autopsy data to classify the cause of death.

Main Results:

  • COVID-19 pneumonia was identified as the most frequent cause of death in the studied autopsy series.
  • Typical PMCT findings associated with viral pneumonia, such as GGO and consolidations, were frequently observed in SARS-CoV-2 deaths.
  • These characteristic PMCT findings were instrumental in classifying deaths as COVID-19-associated.

Conclusions:

  • PMCT is a rapid and effective noninvasive method for identifying pulmonary findings in deceased individuals with COVID-19 pneumonia.
  • Characteristic PMCT findings are common in SARS-CoV-2-associated deaths and aid in determining COVID-19 as the cause of death.
  • PMCT plays a significant role in the forensic identification of pulmonary pathology in the context of the COVID-19 pandemic.