Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

3.4K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.4K
Hair Cells01:22

Hair Cells

43.2K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
43.2K
The Cochlea01:13

The Cochlea

48.7K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
48.7K
Auditory Pathway01:15

Auditory Pathway

6.4K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
6.4K
Action Potentials01:41

Action Potentials

139.5K
Overview
139.5K
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

9.5K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
9.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The role of endoplasmic reticulum stress in insulin resistance of type 2 diabetes].

Sheng li ke xue jin zhan [Progress in physiology]·2012
Same author

EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation.

Journal of immunology (Baltimore, Md. : 1950)·2012
Same author

Cu(II)-catalyzed asymmetric hydrosilylation of diaryl- and aryl heteroaryl ketones: application in the enantioselective synthesis of orphenadrine and neobenodine.

Chemistry (Weinheim an der Bergstrasse, Germany)·2012
Same author

T-bet acts as a powerful adjuvant in Ag85B DNA‑based vaccination against tuberculosis.

Molecular medicine reports·2012
Same author

Aspirin-triggered lipoxin Aâ‚„ attenuates lipopolysaccharide-induced intracellular ROS in BV2 microglia cells by inhibiting the function of NADPH oxidase.

Neurochemical research·2012
Same author

Preparation and time-gated luminescence bioimaging applications of long wavelength-excited silica-encapsulated europium nanoparticles.

Nanoscale·2012

Related Experiment Video

Updated: Nov 16, 2025

Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques
07:31

Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques

Published on: September 27, 2011

15.4K

Modulation of Neuronal Potassium Channels During Auditory Processing.

Jing Wu1, Leonard K Kaczmarek1

  • 1Department of Pharmacology, Yale University School of Medicine, New Haven, CT, United States.

Frontiers in Neuroscience
|February 22, 2021
PubMed
Summary
This summary is machine-generated.

Auditory brainstem neurons use potassium channels to precisely encode sound features for accurate sound localization. Modulation of these channels is crucial for extracting auditory information and preventing decoding deficits.

Keywords:
MNTBcocktail party effectfiring patternpotassium channelssound localization

More Related Videos

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue
11:08

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue

Published on: September 5, 2015

14.1K
In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity
10:31

In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity

Published on: August 18, 2020

5.8K

Related Experiment Videos

Last Updated: Nov 16, 2025

Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques
07:31

Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques

Published on: September 27, 2011

15.4K
Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue
11:08

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue

Published on: September 5, 2015

14.1K
In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity
10:31

In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity

Published on: August 18, 2020

5.8K

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Computational Neuroscience

Background:

  • Auditory stimuli extraction and localization, like in the 'cocktail-party' effect, depend on auditory brainstem nuclei.
  • Neurons in these nuclei must encode sound timing, frequency, and intensity with high fidelity.
  • Accurate sound localization relies on neurons firing at high rates with temporal accuracy, influenced by intrinsic electrical properties.

Purpose of the Study:

  • To review the critical role of potassium channel modulation in auditory brainstem neurons.
  • To explore how these modulations shape neuronal firing patterns and accuracy.
  • To discuss insights from human gene mutations and the impact of channel regulation errors.

Main Methods:

  • Review of existing research on potassium currents in auditory brainstem neurons.
  • Analysis of studies on the impact of auditory environment changes on neuronal membrane properties.
  • Examination of findings from human gene mutations affecting sound localization.

Main Results:

  • Potassium currents in auditory brainstem neurons are not fixed but are modulated by the auditory environment.
  • Modulation of potassium channels is critical for shaping neuronal firing patterns and accuracy.
  • Human gene mutations impairing sound localization highlight the role of specific potassium channels.

Conclusions:

  • Regulation of potassium channels is essential for high-fidelity auditory information processing.
  • Short-term and long-term modulation of these channels optimizes auditory extraction.
  • Errors in potassium channel regulation lead to deficits in decoding complex auditory information.