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Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?
Cássio Morais Loss1,2, Lucas Teodoro1, Gabriela Doná Rodrigues1
1Molecular and Behavioral Neuroscience Laboratory, Departamento de Farmacologia, Universidade Federal de São Paulo, São Paulo, Brazil.
Cannabidiol (CBD) shows promise for neurodevelopmental disorders like schizophrenia and autism spectrum disorder (ASD). Research suggests CBD may offer benefits for these conditions, warranting further investigation.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Schizophrenia and Autism Spectrum Disorder (ASD) are significant neurodevelopmental disorders associated with severe functional impairments.
- Current therapeutic options for these conditions are limited, highlighting the need for novel treatment strategies.
Purpose of the Study:
- To review preclinical and clinical evidence on the efficacy of cannabidiol (CBD) in managing neurodevelopmental disorders.
- To investigate the behavioral, molecular, and functional impacts of chronic CBD treatment during neurodevelopment in schizophrenia and ASD.
Main Methods:
- Systematic review of existing clinical and preclinical studies.
- Analysis of research focusing on chronic treatment with CBD and cannabidivarin (for ASD) during critical neurodevelopmental periods.
Main Results:
- Preclinical and clinical data suggest that CBD possesses therapeutic potential for schizophrenia and ASD.
- Evidence indicates CBD may positively influence the neurodevelopmental trajectory in these disorders.
Conclusions:
- Cannabidiol (CBD) emerges as a promising therapeutic candidate for schizophrenia and ASD.
- Further research is essential to validate and strengthen the use of CBD in clinical practice for these neurodevelopmental conditions.
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