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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
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Coherent Raman Scattering Microscopy in Oncology Pharmacokinetic Research

Junjie Zeng1, Wenying Zhao1, Shuhua Yue1,2

  • 1Institute of Medical Photonics, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.

Frontiers in Pharmacology
|February 22, 2021
PubMed

Insights

Coherent Raman scattering microscopy offers a label-free imaging solution to overcome challenges in anti-cancer drug development. This advanced technique provides high-resolution, chemical insights for improved oncology pharmacokinetic studies.

Area of Science:

  • Oncology
  • Pharmacology
  • Microscopy
  • Chemical Imaging

Background:

  • High attrition rates of anti-cancer drugs in clinical development are a significant bottleneck.
  • Current methods lack quantitative, selective, and rapid readouts of drug activity in situ.
  • Fluorescent labels used in microscopy can interfere with drug molecules.

Purpose of the Study:

  • To review the latest applications of coherent Raman scattering (CRS) microscopy in oncology.
  • To highlight CRS microscopy as an emerging platform for facilitating pharmacokinetic research of anti-cancer drugs.

Main Methods:

  • Coherent Raman scattering microscopy enables label-free imaging.
  • This technique offers chemical selectivity, high sensitivity, and high spatial resolution.
  • It allows for high-speed imaging without perturbing drug molecules.

Main Results:

  • CRS microscopy has advanced the understanding of pharmaceutical materials in the solid state.
  • It has improved the study of pharmacokinetics for anti-cancer drugs and nanocarriers in vitro and in vivo.
  • CRS microscopy overcomes limitations associated with fluorescent labeling.

Conclusions:

  • Coherent Raman scattering microscopy is a powerful, emerging tool for oncology research.
  • Its label-free, high-resolution capabilities address critical needs in drug development.
  • CRS microscopy significantly enhances the study of anti-cancer drug pharmacokinetics.
Keywords:
Raman taganti-cancer drugcoherent Raman scattering microscopydrug dissolutiondrug distributiondrug metabolismlabel-freepharmacology

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