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Updated: Nov 16, 2025

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
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Published on: July 6, 2017

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circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway

Wei Zhang1, Gang Wu1, Peichun Sun1

  • 1Department of Gastrointestinal Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University, Zhengzhou, Henan 450003, People's Republic of China.

Journal of Cancer
|February 22, 2021
PubMed

Insights

Circular RNAs (circRNAs) are linked to diseases like cancer. This study identifies a novel circRNA, circ_SMAD2, as elevated in colorectal cancer (CRC), promoting tumor progression and invasion.

Area of Science:

  • Molecular Biology
  • Oncology

Background:

  • Circular RNAs (circRNAs) are implicated in various diseases, but their specific roles in colorectal cancer (CRC) remain largely uncharacterized.
  • Colorectal cancer (CRC) is a significant global health concern with a need for better understanding of its molecular drivers.

Purpose of the Study:

  • To investigate the role and mechanism of a novel circRNA, Hsa_circ_0000847 (circ_SMAD2), in colorectal cancer (CRC).

Main Methods:

  • Quantification of circ_SMAD2 expression in CRC cell lines and tissues.
  • Correlation analysis between circ_SMAD2 levels and CRC clinicopathological features.
  • In vitro and in vivo functional assays to assess the impact of circ_SMAD2 on CRC progression.
  • Mechanistic studies to elucidate the molecular pathway involving circ_SMAD2, miR-1258, and RPN2.

Main Results:

  • circ_SMAD2 expression was significantly elevated in CRC cell lines and tissues compared to normal controls.
  • High circ_SMAD2 levels were positively correlated with advanced CRC clinicopathological features.
  • circ_SMAD2 overexpression promoted CRC cell invasion, proliferation, and tumor growth in vitro and in vivo.
  • circ_SMAD2 was found to enhance Ribophorin II (RPN2) expression by sponging miR-1258.

Conclusions:

  • circ_SMAD2 plays a crucial role in promoting colorectal cancer progression, invasion, and proliferation.
  • circ_SMAD2 acts via the circ_SMAD2/miR-1258/RPN2 axis.
  • circ_SMAD2 represents a potential diagnostic and prognostic biomarker for colorectal cancer.
Keywords:
RPN2circ_SMAD2colorectal cancermiR-1258

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