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Covid-19 and Thrombotic Thrombocytopenic Purpura: A Case Report

Maryam Darnahal1, Hamed Azhdari Tehrani1, Mohammad Vaezi2

  • 1Department of Hematology and Medical Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

International Journal of Hematology-Oncology and Stem Cell Research
|February 22, 2021
PubMed

Insights

Thrombotic thrombocytopenic purpura (TTP) is a rare condition linked to COVID-19. This case report details the fourth patient identified with TTP associated with the novel coronavirus, highlighting a potential link.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Thrombotic microangiopathies (TMAs) arise from endothelial injury, activating coagulation and leading to organ dysfunction.
  • Platelet consumption and red blood cell injury are hallmarks of TMAs.

Observation:

  • This case report describes the fourth patient diagnosed with thrombotic thrombocytopenic purpura (TTP).
  • The patient presented with TTP in association with COVID-19.

Findings:

  • COVID-19 can precipitate TTP, a serious thrombotic microangiopathy.
  • The association between SARS-CoV-2 infection and TTP is increasingly recognized.

Implications:

  • Understanding this association is crucial for timely diagnosis and management of TTP in COVID-19 patients.
  • Further research is warranted to elucidate the pathogenic mechanisms linking COVID-19 and TTP.
  • Early recognition and treatment may improve outcomes for patients with concurrent COVID-19 and TTP.

Keywords:
Covid-19Plasma exchangeThrombotic thrombocytopenic turpura (TTP)

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