Related Experiment Video
Updated: Jul 15, 2026

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
Published on: October 17, 2018
COVID-19-associated spontaneous subacute subdural haematoma: report of two cases
A Tabibkhooei1, J Hatam1, M Mokhtari1
1Department of Neurology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Insights
COVID-19 infection can cause spontaneous subdural hematomas, a serious brain bleed. Prompt neurological evaluation and imaging are crucial for patients with altered consciousness during COVID-19.
Area of Science:
- Neurology
- Infectious Diseases
- Neurosurgery
Background:
- The COVID-19 pandemic has led to various health complications, including neurological disorders.
- Vascular complications associated with COVID-19 have been increasingly reported globally.
Observation:
- Two patients with COVID-19 developed spontaneous subdural hematomas without prior trauma or vascular injury.
- Both patients presented with lethargy and unresponsiveness in the intensive care unit.
Findings:
- Emergent craniotomy was performed on both individuals, with one patient showing significant improvement and discharge.
- The second patient did not improve neurologically and unfortunately died post-surgery.
Implications:
- Subdural hematomas are a potential hemorrhagic complication of COVID-19, possibly due to several underlying mechanisms.
- Altered consciousness in COVID-19 patients necessitates urgent brain imaging and neurological assessment to rule out conditions like subdural hematoma.
Abstract:
Since March 2020, the pandemic of coronavirus disease 2019 (COVID-19) has become a threat to global health. Several kinds of coronavirus-associated disorders, including vascular involvements with neurological symptoms, have been reported worldwide. Here, we describe two individuals with COVID-19 with no history of traumatic brain injury nor of vascular injuries, who developed spontaneous subdural haematoma in a subacute process. Both individuals became lethargic and unresponsive during admission in the intensive care unit. Both have undergone emergent craniotomy with acceptable outcome. The first patient improved significantly and was discharged a week after surgery. However, the second individual had no improvement on her consciousness and died 3 days after surgery. Haemorrhagic events, including subdural haematoma, can happen during COVID-19 infection with several possible mechanisms. Brain imaging and further neurological evaluation must be performed in any individuals with COVID-19 who show signs of alteration in their state of consciousness.
More Related Videos
Related Concept Videos
Hemorrhagic Stroke l: Introduction
Hemorrhagic Stroke ll: Pathophysiology
Brain Abscess l: Introduction

