Therapeutic Strategies in the Management of COVID-19

Area of Science:

• Virology
• Infectious Diseases
• Pharmacology

Background:

• The global emergence of SARS-CoV-2 (COVID-19) since December 2019 has led to a pandemic, overwhelming healthcare systems worldwide.
• Current treatment strategies focus on isolating patients and utilizing existing antivirals approved for SARS, MERS, and other viral infections, with some under clinical investigation.
• No specific antiviral therapies or vaccines are currently clinically approved for COVID-19, necessitating drug repurposing to mitigate the healthcare burden.

Purpose of the Study:

• To review and discuss various therapeutic strategies for managing COVID-19 patients.
• To highlight the potential of repurposed drugs, including antivirals, US-FDA approved medications, and traditional remedies.
• To emphasize the role of monoclonal antibodies and plant-based therapeutics in COVID-19 treatment.

Main Methods:

• Literature review of existing therapeutic approaches for COVID-19.
• Discussion of drug repurposing strategies, including antivirals, anti-malarials, anti-parasitics, and anti-HIV medications.
• Exploration of plant-based therapeutics, traditional medicines, and monoclonal antibody treatments.

Main Results:

• The study identifies several therapeutic avenues being explored for COVID-19 management.
• Repurposing of existing drugs and antivirals shows promise in alleviating symptoms and reducing healthcare burdens.
• Plant-based, traditional medicines, and monoclonal antibodies are also discussed as potential treatment options.

Conclusions:

• Effective therapeutic strategies are crucial for managing the COVID-19 pandemic.
• Drug repurposing and the exploration of diverse treatments like plant-based therapies and monoclonal antibodies are vital for patient care.
• Further research and clinical validation are needed to establish definitive treatments for COVID-19.