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Related Experiment Video

Updated: Nov 16, 2025

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
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Ascorbic Acid Prevents Vascular Endothelial Dysfunction Induced by Electronic Hookah (Waterpipe) Vaping.

Mary Rezk-Hanna1, Douglas R Seals2, Matthew J Rossman2

  • 1School of Nursing University of California Los Angeles CA.

Journal of the American Heart Association
|February 22, 2021
PubMed
Summary

Electronic hookah (e-hookah) vaping impairs vascular function and endothelial function by increasing oxidative stress. Ascorbic acid prevented these adverse effects, suggesting a role for antioxidants in mitigating e-hookah-induced harm.

Keywords:
ascorbic acidelectronic hookahelectronic waterpipeendothelial functionoxidative stress

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Area of Science:

  • Cardiovascular Research
  • Pulmonology
  • Toxicology

Background:

  • Electronic hookah (e-hookah) use is rising among youth, despite misconceptions about aerosol safety.
  • E-hookahs deliver nicotine via fine and ultrafine particles, potentially impairing endothelial function and nitric oxide bioavailability.
  • Oxidative stress from e-hookah vaping may contribute to vascular dysfunction.

Purpose of the Study:

  • To investigate the acute effects of e-hookah vaping on endothelial function.
  • To determine the role of oxidative stress in e-hookah-induced vascular impairment.
  • To assess the impact of ascorbic acid (an antioxidant) on e-hookah vaping effects.

Main Methods:

  • Twenty-six healthy young adult habitual hookah smokers participated in a 30-minute e-hookah vaping session.
  • Endothelial function was measured using brachial artery flow-mediated dilation (FMD).
  • Plasma total antioxidant capacity, nicotine, and exhaled carbon monoxide were measured. Ascorbic acid infusion was administered to assess its protective effects (n=11). Sham-vaping controls were conducted (n=10).

Main Results:

  • E-hookah vaping significantly increased plasma nicotine and mean arterial pressure.
  • Acutely decreased FMD following e-hookah vaping (5.79% to 4.39%).
  • Ascorbic acid administration increased baseline FMD and prevented the FMD reduction caused by e-hookah vaping.

Conclusions:

  • E-hookah vaping acutely impairs vascular endothelial function.
  • Oxidative stress is a likely mechanism underlying e-hookah-induced vascular impairment.
  • Findings suggest that e-hookah use may accelerate cardiovascular disease development over time.