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Use of anticancer peptides as an alternative approach for targeted therapy in breast cancer: a review
Ala Orafaie1, Ahmad Reza Bahrami1,2, Maryam M Matin1,3
1Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.
Abstract:
Breast cancer is the most common cancer in women worldwide. Traditional therapies are expensive and cause severe side effects. Targeted therapy is a powerful method to circumvent the problems of other therapies. It also allows drugs to localize at predefined targets in a selective manner. Currently, there are several monoclonal antibodies which target breast cancer cell surface markers. However, using antibodies has some limitations. In the last two decades, many investigators have discovered peptides that may be useful to target breast cancer cells. In this article, we provide an overview on anti-breast cancer peptides, their sources and biological activities. We further discuss the pros and cons of using anticancer peptides with further emphasis on how to improve their effectiveness in cancer therapy.
Insights
Anticancer peptides offer a promising targeted therapy for breast cancer, overcoming limitations of traditional treatments and antibody-based approaches. Research explores their sources, activities, and potential to enhance cancer treatment effectiveness.
Area of Science:
- Oncology
- Biotechnology
- Pharmacology
Background:
- Breast cancer is a leading global cancer in women.
- Traditional therapies present challenges like high cost and severe side effects.
- Targeted therapy offers a selective approach to drug delivery.
Purpose of the Study:
- To provide an overview of anti-breast cancer peptides.
- To discuss the sources and biological activities of these peptides.
- To evaluate the potential of peptides in breast cancer treatment.
Main Methods:
- Literature review of anti-breast cancer peptides.
- Analysis of peptide sources and biological functions.
- Discussion of advantages and disadvantages of peptide-based therapy.
Main Results:
- Peptides have emerged as viable alternatives to traditional breast cancer therapies.
- Various peptides demonstrate significant anticancer activities.
- Antibody-based therapies have limitations that peptides may address.
Conclusions:
- Peptides represent a promising avenue for targeted breast cancer therapy.
- Further research is needed to optimize peptide effectiveness and overcome limitations.
- Peptide-based strategies hold potential for improved breast cancer treatment outcomes.
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