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Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune

Amir Hossein Mohseni1, Vincenzo Casolaro2, Luis G Bermúdez-Humarán3

  • 1Department of Microbiology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University , Tehran, Iran.

Gut Microbes
|February 22, 2021
PubMed

Insights

Probiotics modulate the PI3K/Akt/mTOR pathway, impacting immune responses and various diseases. Further human studies are needed to confirm their therapeutic potential in conditions like gastrointestinal disorders and aging.

Area of Science:

  • Immunology
  • Molecular Biology
  • Microbiology

Background:

  • The phosphatidylinositol-3-kinase (PI3K)/protein kinase B or Akt (PKB/Akt) and mammalian target of rapamycin (mTOR) signaling pathways are crucial for immune system regulation.
  • Aberrant activation of these pathways is linked to numerous human diseases.
  • Probiotics and their metabolites are increasingly recognized for their influence on these pathways.

Purpose of the Study:

  • To review the current evidence on the relationship between probiotics and the PI3K/Akt/mTOR signaling pathways.
  • To explore the role of these pathways in various health and disease conditions influenced by probiotics.
  • To summarize the impact of probiotics and their metabolites on PI3K/Akt/mTOR signaling.

Main Methods:

  • Review of recent peer-reviewed studies.
  • Analysis of in vitro and in vivo experimental models.
  • Examination of the causal relationship between probiotic exposure and pathway modulation.

Main Results:

  • Probiotics influence the PI3K/Akt/mTOR pathway, affecting immune responses.
  • This interaction is implicated in gastrointestinal disorders, metabolic syndrome, skin diseases, allergy, salmonella infection, and aging.
  • Experimental evidence suggests a significant role for probiotics in modulating these key signaling cascades.

Conclusions:

  • The PI3K/Akt/mTOR pathway is a key mediator of probiotic effects on immune responses and human health.
  • Probiotics show potential in managing various diseases by influencing these signaling pathways.
  • Longitudinal human studies are essential to validate the therapeutic applications of targeting PI3K/Akt/mTOR with probiotics.
Keywords:
bifidobacteriumlactobacillusPI3KaktmTORprobiotics

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