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Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING

Miroslav Smola1, Ondrej Gutten1, Milan Dejmek1

  • 1Gilead Sciences Research Centre at IOCB, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 2, 16610, Prague, Czech Republic.

Angewandte Chemie (International Ed. in English)
|February 22, 2021
PubMed

Keywords:
conformational analysiscyclic dinucleotidesentropyquantum chemistrystrain energy

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