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Updated: Nov 16, 2025

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Acute Disseminated Encephalomyelitis (ADEM): A Demyelinating Disease with Specific Morphological Features
Fleur Cordier1, Lars Velthof1, David Creytens1
1Ghent University Hospital, 60200Ghent University, Ghent, Belgium.
Abstract:
Acute disseminated encephalomyelitis (ADEM) is a rare immune-mediated inflammatory and demyelinating disorder of the central nervous system. Its characteristic perivenular demyelination and inflammation aid in the differential diagnosis with other inflammatory demyelinating diseases. Here, we present a clinical case of ADEM, summarize its histological hallmarks, and discuss pitfalls concerning the most important neuropathological differential diagnoses.
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