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Chronic Kidney Disease I: Introduction01:25

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

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Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

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Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Frequency of tooth brushing as a predictive factor for future kidney function decline.

Keita Hirano1,2,3, Takuro Shimbo4, Yasuhiro Komatsu5,6

  • 1Department of Nephrology, St. Luke's International Hospital, Tokyo, Japan. keita@kuhp.kyoto-u.ac.jp.

Journal of Nephrology
|February 22, 2021
PubMed
Summary

Brushing teeth frequently may slow kidney function decline in individuals with chronic kidney disease (CKD). This study suggests a link between regular tooth brushing and improved renal outcomes, though further research is needed.

Keywords:
Chronic kidney diseaseKidney functionOral and periodontal healthTooth brushing frequency

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Area of Science:

  • Nephrology
  • Periodontology
  • Preventive Medicine

Background:

  • Periodontal diseases are common in chronic kidney disease (CKD) patients.
  • Tooth brushing is crucial for oral health and preventing periodontal diseases.
  • The link between tooth brushing frequency and kidney function decline is not well-established.

Purpose of the Study:

  • To investigate the association between tooth brushing frequency and kidney function decline.
  • To evaluate the impact of tooth brushing on composite renal outcomes in a large cohort.

Main Methods:

  • Retrospective longitudinal study including 76,472 participants.
  • Assessed tooth brushing frequency and tracked composite renal outcomes (eGFR reduction, low eGFR, dialysis).
  • Used multivariate analyses with generalized estimating equations, adjusting for covariates and stratifying by CKD risk.

Main Results:

  • Brushing teeth 1-2 times daily was linked to significantly lower composite renal outcomes (aOR 0.26).
  • Brushing after every meal also showed a protective association (aOR 0.65).
  • The protective effect of brushing 1-2 times daily was observed in low and moderate CKD risk groups.

Conclusions:

  • Frequent tooth brushing may be associated with slower kidney function decline.
  • Oral health practices could influence renal outcomes, with potential implications for systemic health.
  • Further longitudinal studies are needed to confirm the role of tooth brushing in improving renal outcomes.