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Impact of Smoking, Obesity and Maternal Diabetes on SHBG Levels in Newborns

Banu Kucukemre Aydin1, Beril Yasa2, Joseph P Moore3

  • 1Division of Pediatric Endocrinology, Metabolism and Diabetes, Istanbul University, Istanbul, Turkey.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
|February 22, 2021
PubMed

Insights

Maternal diabetes is linked to lower sex hormone-binding globulin (SHBG) levels in newborns, potentially indicating a lifelong metabolic health risk. Maternal smoking did not directly impact infant SHBG levels.

Area of Science:

  • Endocrinology
  • Neonatal Health
  • Metabolic Disorders

Background:

  • Low sex hormone-binding globulin (SHBG) levels are associated with insulin resistance and diabetes.
  • Infants born to mothers with obesity, diabetes, or who smoke are at increased risk for developing obesity and diabetes later in life.

Purpose of the Study:

  • To investigate the impact of maternal diabetes, obesity, and smoking on newborn SHBG levels.

Main Methods:

  • Cross-sectional study involving 98 healthy newborns and their mothers.
  • Cord blood and second-day blood samples collected for SHBG and insulin measurements.
  • Maternal history of diabetes and smoking status recorded.

Main Results:

  • Newborns of mothers with diabetes exhibited significantly lower SHBG levels in cord blood and on day 2 compared to controls.
  • Maternal diabetes was independently associated with lower SHBG levels, even after adjusting for maternal factors.
  • No significant difference in SHBG levels was observed in infants of mothers who were overweight-obese (without diabetes) or smokers compared to controls.

Conclusions:

  • Lower SHBG levels in newborns of diabetic mothers may serve as an early marker for lifelong metabolic health risks.
  • Maternal smoking during pregnancy does not appear to directly affect fetal SHBG levels.
Abstract

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