Relationship between insulin-like growth factor-1, insulin resistance and metabolic profile with pre-obesity and

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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

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Marina Jaksic1,2, Milica Martinovic2, Najdana Gligorovic-Barhanovic3

  • 1Center for Laboratory Diagnostics, Clinical Center of Montenegro, Institute for Children's Diseases, Podgorica, Montenegro.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|February 22, 2021
PubMed

Insights

Elevated insulin-like growth factor-1 standard deviation score (IGF-1 SDS) and total body fat (TBF) predict childhood obesity. These findings highlight IGF-1

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Health
  • Obesity Research

Background:

  • Childhood obesity is a global health concern with complex etiological factors.
  • The precise role of insulin-like growth factor-1 (IGF-1) in pediatric obesity remains debated.
  • Understanding metabolic profiles associated with obesity is crucial for effective intervention.

Purpose of the Study:

  • To investigate the relationship between IGF-1, insulin resistance (IR), and metabolic markers in pre-obese and obese children.
  • To identify predictors of nutritional status and insulin resistance in pediatric populations.
  • To elucidate the role of IGF-1 in the pathophysiology of childhood obesity.

Main Methods:

  • A cross-sectional study involving 201 children aged 7-15 years, categorized into normal-weight, pre-obese, and obese groups.
  • Analysis of serum IGF-1, insulin, fasting blood glucose (FBG), lipid profiles, ALT, and uric acid (UA).
  • Calculation of IGF-1 standard deviation score (SDS), HOMA-IR, and anthropometric/body composition parameters including waist-to-height ratio (WtHR) and total body fat (TBF).

Main Results:

  • Pre-obese and obese children exhibited significantly higher IGF-1 SDS, FBG, insulin, HOMA-IR, UA, ALT, and triglycerides, with lower HDL-c compared to normal-weight children.
  • Obese children had increased WtHR and LDL-c.
  • IGF-1 SDS was positively correlated with fat-free mass and total body water, and negatively with LDL-c in obese children. HOMA-IR and insulin correlated positively with age and TBF, and negatively with HDL-c in pre-obese/obese children.
  • Multivariate analyses identified IGF-1 SDS and TBF as significant predictors of nutritional status, while FBG and UA predicted insulin resistance.

Conclusions:

  • IGF-1 SDS and TBF are significant predictors of nutritional status in children.
  • FBG and UA are identified as predictors of insulin resistance.
  • Further research is warranted to fully understand IGF-1's role in obesity and its associated comorbidities.
Abstract

Keywords:
childhood obesityinsulin resistanceinsulin-like growth factor-1metabolic profile

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