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Endocrine disrupting chemicals and bone.
1Department of Pediatric Endocrinology and Diabetes, Marmara University School of Medicine, Istanbul, Turkey.
Best Practice & Research. Clinical Endocrinology & Metabolism
|February 23, 2021
Summary
Endocrine-disrupting chemicals (EDCs) harm bone health by interfering with hormone systems. This review details how EDCs impact bone modeling and remodeling, affecting stem cells and leading to bone disruption.
Area of Science:
- Endocrinology
- Toxicology
- Bone Biology
Background:
- Endocrine-disrupting chemicals (EDCs) interfere with the endocrine system's function.
- EDCs modulate hormone receptors, alter hormone metabolism, and affect signaling pathways.
- Complex dose-response curves characterize EDC effects.
Purpose of the Study:
- To review recent discoveries on the bone-disrupting effects of environmental EDCs.
- To highlight findings from basic molecular mechanisms to clinical implications.
Main Methods:
- Review of current scientific literature on EDCs and bone health.
- Analysis of molecular and cellular mechanisms of EDC action on bone.
- Examination of clinical evidence linking EDCs to bone disorders.
Main Results:
- EDCs negatively impact bone modeling and remodeling.
- Mechanisms include altered hormone synthesis, growth factor release, and stem cell differentiation.
- Specific EDC groups like PFAS, phthalates, BPA, organotins, alkylphenols, and dioxins are implicated.
Conclusions:
- Accumulating evidence confirms the bone-disrupting potential of various EDCs.
- Understanding these effects is crucial for public health and clinical practice.
Keywords:
bisphenolsbonedioxinsendocrine disrupting chemicalsperfluoroalkyl substancesphthalate estersMore Related Videos
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