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Sarcoidosis manifesting during treatment with secukinumab for psoriatic arthritis
Colm Kirby1, Darragh Herlihy2, Lindsey Clarke3
1Rheumatology, Tallaght University Hospital, Dublin, Ireland colmkirby11@gmail.com.
Abstract:
Sarcoidosis is a multisystem inflammatory disorder of uncertain aetiology. There are numerous case reports of sarcoidosis occurring during treatment with biological immunotherapies. Here, we describe the case of a 52-year-old woman with psoriatic arthritis who developed multisystem sarcoidosis while being treated with secukinumab (anti-interleukin-17A) therapy which, to our knowledge, is the first such case. We discuss existing literature and hypothesise that IL-17 blockade may precipitate the development of granulomatous disease.
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