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Related Experiment Videos

Verapamil abolishes exercise-induced regional contractile dysfunction in dogs.

W Schneider1, S Ehrendorfer, G Krumpl

  • 1Dept. Pharmacol., University of Vienna, Austria.

Methods and Findings in Experimental and Clinical Pharmacology
|February 1, 1988
PubMed
Summary

Calcium channel blocker verapamil improved regional heart function during exercise in a canine model. This study investigated verapamil

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Area of Science:

  • Cardiovascular Pharmacology
  • Myocardial Ischemia Research

Background:

  • Exercise-induced myocardial dysfunction models angina pectoris.
  • Calcium antagonists are potential treatments for such conditions.

Purpose of the Study:

  • To evaluate verapamil's effects on hemodynamics and regional myocardial function during exercise-induced dysfunction.
  • To compare verapamil's efficacy with bepridil.

Main Methods:

  • Canine model with treadmill exercise and induced coronary stenosis.
  • Chronic instrumentation for hemodynamic and sonomicrometry measurements.
  • Intravenous verapamil administration (0.3 mg/kg) post-control runs.

Main Results:

  • Verapamil increased resting heart rate due to blood pressure reduction.

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  • Exercise-induced increases in heart rate and rate-pressure product were reduced.
  • Regional contractile dysfunction during exercise was significantly improved.

    • Conclusions:

    • Verapamil effectively improves regional myocardial function in exercise-induced dysfunction.
    • The drug's hemodynamic effects contribute to improved regional perfusion.
    • Verapamil demonstrated comparable efficacy to bepridil in this model.