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Related Experiment Videos

BEQUIV interactive microcomputer program for testing equivalence in two-group comparative bioavailability trials.

M Durisová1, T Trnovec

  • 1Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.

Methods and Findings in Experimental and Clinical Pharmacology
|February 1, 1988
PubMed
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The BEQUIV program tests for equivalence in bioavailability trials using the Anderson and Hauck method. This BASIC program offers flexibility and is designed for users without statistical expertise.

Area of Science:

  • Pharmacokinetics
  • Biostatistics
  • Computational Science

Background:

  • Comparative bioavailability trials are crucial for drug development.
  • Statistical methods are essential for assessing drug equivalence.
  • Accessible software facilitates wider application of statistical methods.

Purpose of the Study:

  • To introduce the BEQUIV program for testing equivalence in two-group comparative bioavailability trials.
  • To provide a user-friendly tool for non-statistically trained users.
  • To demonstrate the program's functionality using a pharmacokinetic example.

Main Methods:

  • The BEQUIV program utilizes an algorithm based on the Anderson and Hauck approach.
  • It is written in the BASIC programming language.

Related Experiment Videos

  • Includes options for calculating statistical parameters and performing analysis of variance.

    • Main Results:

    • The program successfully implements the Anderson and Hauck method for equivalence testing.
    • Demonstrated performance through a numerical example from pharmacokinetic literature.
    • Offers flexibility with various calculation options.

    Conclusions:

    • BEQUIV is a valuable tool for assessing bioequivalence in clinical trials.
    • Its design caters to users with limited statistical backgrounds.
    • Facilitates the application of established statistical methods in bioavailability research.