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Diagnosis and Treatment of Iron Deficiency in Heart Failure: OFICSel study by the French Heart Failure Working Group

Theo Pezel1,2, Etienne Audureau3, Jacques Mansourati4

  • 1Department of Cardiology, Centre Hospitalo-Universitaire (CHU) Lariboisière, AP-HP, 2 rue Ambroise Paré, Paris, 75010, France.

ESC Heart Failure
|February 23, 2021
PubMed

Insights

Many heart failure patients have iron deficiency but are not tested or treated per guidelines. Cardiologists should improve adherence to European Society of Cardiology recommendations for iron deficiency diagnosis and treatment in heart failure.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Clinical Research

Background:

  • Iron deficiency (ID) affects approximately 50% of heart failure (HF) patients.
  • European Society of Cardiology (ESC) guidelines recommend ID testing and intravenous iron supplementation (IS) for specific HF populations.

Purpose of the Study:

  • To evaluate the real-world prevalence of ID in HF patients.
  • To assess the application of ESC guidelines for ID diagnosis and IS in HF.
  • To identify clinical characteristics associated with ID and its management.

Main Methods:

  • The study utilized data from the French OFICSel registry, including 2822 patients hospitalized for HF.
  • Data were collected via surveys from 300 cardiologists and patients.
  • Analysis focused on ID testing rates, diagnosis, and IS application, including intravenous vs. oral routes.

Main Results:

  • Only 38.1% of HF patients were tested for ID, with 33.9% diagnosed.
  • Among diagnosed ID patients, 46.2% received IS (76.2% intravenous).
  • In HF with reduced ejection fraction (HFrEF) patients with ID, only 49.3% received IS (79.8% intravenous), falling short of guideline recommendations.

Conclusions:

  • Real-world ID diagnostic testing in HF patients is suboptimal.
  • Adherence to ESC guidelines for IS in HFrEF patients with ID is low.
  • Cardiologists need encouragement to implement ESC guidelines for optimal HF patient care.
Abstract

Keywords:
DiagnosisGuidelinesHeart failureIron deficiencyIron supplementation

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