Related Experiment Video
Updated: Nov 16, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
A Web-Based Computer-Tailored Program to Improve Treatment Adherence in Patients With Type 2 Diabetes: Randomized
Stan Vluggen1, Math Candel2, Ciska Hoving1
1Department of Health Promotion, Maastricht University, Maastricht, Netherlands.
This study shows an eHealth program significantly improved overall treatment adherence for type 2 diabetes mellitus (T2DM) patients. The intervention led to better adherence to healthy lifestyles and medical treatments.
Area of Science:
- Digital Health Interventions
- Chronic Disease Management
- Behavioral Medicine
Background:
- Suboptimal adherence to type 2 diabetes mellitus (T2DM) treatment behaviors is a significant challenge.
- Nonadherence often spans multiple treatment behaviors, including lifestyle and medication.
- eHealth programs offer a promising avenue for improving adherence in T2DM management.
Purpose of the Study:
- To evaluate the effectiveness of a computer-tailored eHealth program designed to enhance treatment adherence in patients with T2DM.
- To assess the impact of the eHealth intervention on multiple adherence behaviors within a randomized controlled trial framework.
Main Methods:
- A randomized controlled trial was conducted with 478 T2DM patients, comparing a 6-month eHealth program intervention group to a waiting-list control group.
- Outcome measures included physical activity, unhealthy snack intake, and adherence to oral hypoglycemic agents and insulin therapy.
- Mixed linear regression analyses were used to determine the intervention's effect on overall and specific treatment adherence behaviors.
Main Results:
- The eHealth intervention group showed a significant improvement in overall treatment adherence compared to the control group (Cohen's d=0.27, P=.03).
- A significant reduction in caloric intake from unhealthy snacks was observed in the intervention group (d=0.36, P=.002).
- No significant changes were found for adherence to physical activity, oral hypoglycemic agents, or insulin therapy.
Conclusions:
- The developed multibehavior eHealth program effectively improved overall treatment adherence in T2DM patients.
- Wide-scale implementation of this eHealth intervention is recommended to maximize its personal, societal, and economic benefits.
Related Concept Videos
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Diabetes Mellitus: Type 2 and Gestational
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Therapeutic Drug Monitoring: Affecting Factors

