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Updated: Nov 16, 2025
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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
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Cardiovascular calcifications in kidney transplant recipients
Manuel Alfredo Podestà1, David Cucchiari2, Paola Ciceri3
1Renal Division, Department of Health Sciences, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy.
Summary
Vascular calcification is common in kidney transplant recipients (KTRs), increasing cardiovascular event risk. This review explores KTR calcification causes, features, and prevention strategies.
Area of Science:
- Nephrology
- Cardiology
- Transplantation Medicine
Background:
- Vascular and valvular calcifications are highly prevalent in kidney transplant recipients (KTRs).
- These calcifications are linked to increased cardiovascular events, the primary cause of mortality in KTRs.
- Few studies have focused on cardiovascular calcification post-kidney transplantation.
Purpose of the Study:
- To review mediators of cardiovascular calcification in KTRs.
- To describe clinical and radiological features of these calcifications.
- To discuss current and novel preventive strategies.
Main Methods:
- Literature review of established and putative mediators.
- Analysis of clinical and radiological findings.
- Evaluation of existing and emerging preventive strategies.
Main Results:
- KTRs face multiple pro-calcifying stimuli despite improved uremia.
- Factors include traditional risks, bone-mineral disorders, inflammation, immunosuppressants, and low calcification inhibitors.
- Strategies to mitigate these factors are crucial.
Conclusions:
- Cardiovascular calcification is a significant concern in KTRs.
- Understanding its pathogenesis is key to developing effective interventions.
- Further research into preventive and therapeutic approaches is warranted.
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