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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Updated: Nov 16, 2025

An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
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Equivalent tumor detection for early and late FAPI-46 PET acquisition.

J Ferdinandus1, L Kessler2, N Hirmas2

  • 1Department of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany. justin.ferdinandus@uk-essen.de.

European Journal of Nuclear Medicine and Molecular Imaging
|February 23, 2021
PubMed
Summary

Early fibroblast activation protein imaging (FAPI-46 PET) at 10 minutes post-injection shows comparable tumor detection to later scans. This finding supports using earlier imaging times for improved clinical feasibility and scan throughput in cancer diagnostics.

Keywords:
ActivationBiodistributionFAPIFibroblastPETProtein

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Area of Science:

  • Nuclear Medicine
  • Oncology
  • Radiochemistry

Background:

  • Positron emission tomography (PET) with fibroblast activation protein (FAP) ligands is a novel imaging modality.
  • Optimal imaging timing for FAP-PET has not been established.

Purpose of the Study:

  • To compare early (approximately 10 min p.i.) and late (approximately 60 min p.i.) FAPI-46 PET imaging.
  • To determine the optimal uptake time for FAPI-46 PET in cancer patients.

Main Methods:

  • Retrospective study of 69 cancer patients undergoing dual time-point FAPI-46 PET.
  • Imaging performed at early (mean 11 min) and late (mean 66 min) time points post-injection.
  • Analysis of lesion detection and standardized uptake values (SUV).

Main Results:

  • No significant difference in SUVmax of hottest lesions between early and late imaging (P=0.73).
  • Early imaging detected 99.5% of all lesions identified.
  • Significant decrease in mean SUV in organs like the gluteus, liver, and mediastinum from early to late imaging (P<0.001).

Conclusions:

  • Early FAPI-46 PET (around 10 min p.i.) provides equivalent lesion uptake and tumor detection compared to late imaging.
  • Implementing early FAPI-46 PET can enhance feasibility and scan volume in clinical and research settings.