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Updated: Nov 16, 2025

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
Contemporaneous Risk Factors for Visual Acuity in Non-Infectious Uveitis
Maxwell Pistilli1, Sapna S Gangaputra2, Siddharth S Pujari3
1and the Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Research Group** Department of Ophthalmology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Introduction:
We evaluated the associations of clinical and demographic characteristics with visual acuity (VA) with over 5 years in a subspecialty noninfectious uveitis population.
Methods:
Retrospective data from 5,530 noninfectious uveitis patients were abstracted by expert reviewers, and contemporaneous associations of VA with demographic and clinical factors were modeled.
Results:
Patients were a median of 41 years old, 65% female, and 73% white. Eyes diagnosed ≥5 years prior to cohort entry had worse VA (-1.2 lines) than those diagnosed <6 months prior, and eyes with cataract surgery performed prior to entry had worse VA (-5.9 lines) than those performed during follow-up. Vitreous haze (-4.2 lines for 3+ vs quiet), hypotony (-2.5 lines for ≤5 mm Hg vs 6-23 mm Hg), and CNV (-1.8 lines) all were strongly associated with reduced VA.
Conclusion:
Factors associated with reduced VA included well-known structural complications, and lack of subspecialty care during cataract surgery.
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