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Updated: Nov 16, 2025
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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
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Interfacial cationization to quicken redox-responsive drug release.
Yaxin Zheng1, Jie Lei1, Qi Li1
1School of Pharmacy, Key Laboratory of Sichuan Province for Specific Structure of Small Molecule Drugs, Chengdu Medical College, Chengdu, China.
Chemical Communications (Cambridge, England)
|February 23, 2021
Summary
Interfacial cationization enhances redox-responsiveness in lipid-drug nanoassemblies. This creates redox-ultrasensitive nanocarriers for improved intracellular drug delivery.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery
Background:
- Disulfide bond-linked lipid-drug nanoassemblies (NAs) are being explored for drug delivery.
- Improving the redox-responsiveness of these NAs is crucial for efficient intracellular drug release.
Purpose of the Study:
- To investigate the effect of interfacial cationization on the redox-responsiveness of disulfide bond-linked lipid-drug nanoassemblies.
- To develop redox-ultrasensitive nanocarriers for enhanced intracellular drug delivery.
Main Methods:
- Fabrication of lipid-drug nanoassemblies with disulfide bonds.
- Modification of the nanoassembly interface to induce cationization.
- Evaluation of redox-responsiveness through thiol ionization and concentration studies.
- Assessment of intracellular drug delivery efficiency.
Main Results:
- Interfacial cationization significantly increased the redox-responsiveness of the nanoassemblies.
- Alkalization at the cationic interface promoted the generation and concentration of ionized thiols.
- The modified nanoassemblies demonstrated redox-ultrasensitive behavior.
Conclusions:
- Interfacial cationization is a viable strategy to enhance the redox-responsiveness of disulfide bond-linked lipid-drug nanoassemblies.
- This approach can lead to the development of advanced redox-ultrasensitive nanocarriers for effective intracellular drug delivery.
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