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Apolipoprotein M Gene Polymorphism Rs805297 (C-1065A): Association With Type 2 Diabetes Mellitus and Related

Manal Mohammed Tageldeen1, Hosny Badrawy2, Mona Abdelmeguid3

  • 1Clinical Pathology, Assiut General Hospital, Assiut, Egypt.

The American Journal of the Medical Sciences
|February 23, 2021
PubMed
Abstract

Insights

The wild (CC) genotype of Apolipoprotein M (ApoM) polymorphism rs805297 is linked to type 2 diabetes mellitus (T2DM) susceptibility in South Egyptians. The A-allele, however, correlates with hyperglycemia and diabetic retinopathy.

Area of Science:

  • Genetics
  • Endocrinology
  • Ophthalmology

Background:

  • Apolipoprotein M (ApoM) is implicated in type 2 diabetes mellitus (T2DM) susceptibility.
  • Gene promoter polymorphisms in ApoM have shown significant associations with diabetes.
  • Investigating specific ApoM gene variations can elucidate T2DM pathogenesis.

Purpose of the Study:

  • To examine the association between ApoM single nucleotide polymorphism (SNP) rs805297 (C-1065A) and T2DM risk.
  • To evaluate the link between this ApoM polymorphism and T2DM-related microvascular complications.
  • To assess the role of ApoM SNP rs805297 in glycemic control within a South Egyptian population.

Main Methods:

  • A case-control study involving 60 T2DM patients and 60 healthy controls.
  • Measurement of lipid profiles, glucose levels (fasting and postprandial), and creatinine.
  • Genotyping of ApoM SNP rs805297 using PCR-RFLP and sequencing, alongside ApoM level assays via ELISA.

Main Results:

  • Significant differences in ApoM genotypes (p=0.001) and allele frequencies (p=0.019) were observed between T2DM patients and controls.
  • The wild-type (CC) genotype was identified as a risk factor for T2DM in South Egyptians.
  • The C-allele was associated with lower blood glucose levels and reduced risk of retinopathy, while the A-allele correlated with hyperglycemia and retinopathy.

Conclusions:

  • The ApoM polymorphism rs805297 (C-1065A) wild type (CC) is associated with T2DM susceptibility in South Egyptians.
  • This polymorphism may play a role in managing hyperglycemia in T2DM patients.
  • The A-allele of ApoM SNP rs805297 is linked to hyperglycemia and diabetic retinopathy in this population.
Keywords:
Apolipoprotein M polymorphismMicrovascular complicationsNephropathyNeuropathyRetinopathyType 2 Diabetes

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