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Updated: Nov 16, 2025

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

Beyond Standard Practice in Liquid Biopsy: Selective Venous Sampling.

Bruno Damascelli¹, Vladimira Tichà¹, Elena Repetti²

¹Department of Interventional Oncology EMO GVM Centrocuore Columbus, Milano, Italy.

Journal of Vascular and Interventional Radiology : JVIR

|February 23, 2021

Summary

Liquid biopsy offers tumor genetic profiling for cancer diagnosis and treatment. Selective venous sampling can improve the accuracy of this molecular diagnostic method, reducing false negatives.

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Last Updated: Nov 16, 2025

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Area of Science:

Oncology
Molecular Diagnostics
Genetics

Background:

Liquid biopsy is a non-invasive molecular diagnostic technique for cancer genetic profiling.
It aids in primary diagnosis, monitoring minimal residual disease, and guiding targeted therapy.
Common biomarkers include cell-free tumor DNA and circulating tumor cells.

Observation:

Genetic sequencing methods for liquid biopsy can yield false negatives due to limited biological material.
Selective venous sampling was explored as a method to enhance diagnostic accuracy.
Three case studies demonstrated the application of this technique.

Findings:

Selective venous sampling improved the sensitivity and specificity of liquid biopsy.
This targeted approach addresses the challenge of low analyte concentration in circulation.
Enhanced accuracy supports more reliable cancer detection and monitoring.

Implications:

Selective venous sampling represents a promising strategy to overcome limitations in liquid biopsy.
Improved accuracy can lead to earlier and more precise cancer diagnosis and treatment.
This technique has the potential to enhance the clinical utility of liquid biopsies in oncology.