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Efficacy of topical isoconazole nitrate in the treatment of otomycosis

Filiz Gülüstan1, Mehmet Akif Abakay1, Emine Demir2

  • 1Department of Otolaryngology Head and Neck Surgery, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

American Journal of Otolaryngology
|February 23, 2021
PubMed
Abstract

Insights

Topical 1% isoconazole nitrate cream effectively treats otomycosis, resolving ear pain and itching in most patients. This antifungal cream offers a simple and efficient solution for ear infections.

Area of Science:

  • Otolaryngology
  • Dermatology
  • Mycology

Background:

  • Otomycosis, a fungal ear infection, is common and treated with various agents.
  • Current treatment lacks a definitive consensus on the most effective antifungal agent.
  • Isoconazole nitrate is a topical antifungal with potential for otomycosis treatment.

Purpose of the Study:

  • To evaluate the efficacy of topical 1% isoconazole nitrate cream for otomycosis eradication.
  • To determine the resolution rate of otomycosis symptoms and signs using isoconazole nitrate cream.

Main Methods:

  • Prospective study of 43 patients diagnosed with unilateral otomycosis.
  • External ear canal cleaning followed by application of 1% isoconazole nitrate cream.
  • Follow-up examinations on days 5, 10, 15, and 20 to assess symptom relief and otoendoscopic findings.

Main Results:

  • Complete resolution of ear pain and otoendoscopic findings in 100% of patients by the second control.
  • Itching and otoendoscopic findings resolved in 94.3% of patients by the third control examination.
  • The cream demonstrated rapid and high efficacy in symptom and sign resolution.

Conclusions:

  • Topical 1% isoconazole nitrate cream is an effective treatment for otomycosis.
  • The cream is easily applicable and well-tolerated by patients.
  • Isoconazole nitrate cream represents a promising therapeutic option for otomycosis.
Keywords:
Isoconazole nitrateOtomycosisTopical treatment

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