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Applications of Computational Pathology in Head and Neck Cytopathology
Trang K Lollie1, Jeffrey F Krane2
1Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Background:
The application of computational technology to head and neck cytology material has been explored experimentally in several areas with a variety of potential applications.
Summary:
This review summarizes the application of these techniques to the diagnosis of thyroid, salivary gland, and other head and neck fine-needle aspiration specimens. Current limitations and potential future applications in diagnosis are discussed along with the possibilities for therapeutic applications of computational methodology. Key Message: Particularly promising applications include resolving diagnostic uncertainty in indeterminate thyroid aspirates and assessing the tumor microenvironment in response to immunotherapy for squamous cell carcinoma.
