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Is plasma concentration of coenzyme Q10 a predictive marker for left ventricular remodelling after revascularization
Fanny Fontaine1, Damien Legallois2,3, Christian Créveuil4
1Department of Biochemistry, University Hospital of Caen, Caen, France.
Insights
Plasma coenzyme Q10 levels do not predict left ventricular remodelling after ST-elevation myocardial infarction (STEMI). This study found no association, indicating coenzyme Q10 is not a reliable early marker for predicting adverse cardiac remodelling post-STEMI.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Left ventricular remodelling post-myocardial infarction increases heart failure risk.
- Predictive markers for left ventricular remodelling are currently lacking.
- Coenzyme Q10's role in energy production and antioxidant function suggests potential relevance.
Purpose of the Study:
- To investigate if baseline plasma coenzyme Q10 concentrations predict left ventricular remodelling.
- To assess coenzyme Q10 as an early predictor following ST-elevation myocardial infarction (STEMI).
Main Methods:
- Sixty-eight STEMI patients undergoing primary percutaneous coronary intervention were studied.
- 3D-echocardiography assessed left ventricular remodelling at baseline and 6 months.
- Plasma coenzyme Q10 levels were measured using HPLC-MS at admission.
Main Results:
- Plasma coenzyme Q10 concentrations were comparable to existing literature.
- No statistically significant association was found between coenzyme Q10 levels and left ventricular remodelling (P=0.89).
Conclusions:
- Plasma coenzyme Q10 concentration is not a suitable early predictor of left ventricular remodelling after STEMI.
- Further research may be needed to identify reliable predictive markers for post-MI cardiac remodelling.
Background:
Left ventricular remodelling that frequently occurs after acute myocardial infarction is associated with an increased risk of heart failure and cardiovascular death. Although several risk factors have been identified, there is still no marker in clinical use to predict left ventricular remodelling. Plasma concentration of coenzyme Q10, which plays a key role in mitochondrial energy production and as an antioxidant, seems to be negatively correlated with left ventricular function after acute myocardial infarction.
Objective:
The goal of our study was to determine whether the plasma coenzyme Q10 baseline concentrations at time of the ST-elevation myocardial infarction (STEMI) could predict left ventricular remodelling at six months' follow-up.
Methods:
Sixty-eight patients who were admitted to hospital for STEMI and successfully revascularized with primary percutaneous coronary intervention were recruited. All patients underwent a 3D-echocardiography examination within the first four days after percutaneous coronary intervention and six months later then divided into two groups based on the presence or not of left ventricular remodelling. Plasma coenzyme Q10 concentration at the time of percutaneous coronary intervention was determined using high-performance liquid chromatography-tandem mass spectrometry.
Results:
While we found similar plasma coenzyme Q10 concentrations compared with other studies, no association was evidenced between coenzyme Q10 concentrations and left ventricular remodelling (P = 0.89).
Conclusion:
We found no evidence for using plasma coenzyme Q10 concentration as an early prediction marker of left ventricular remodelling after STEMI.
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