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Aberrant Brain Signal Variability and COMT Genotype in Chronic TMD Patients.

M Lim1,2, T D Nascimento1,2, D J Kim1,2

  • 1Headache and Orofacial Pain Effort (H.O.P.E.), Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.

Journal of Dental Research
|February 24, 2021
PubMed
Summary
This summary is machine-generated.

Chronic pain patients with temporomandibular disorder show altered brain signal variability in key pain processing regions. This brain signal variability is linked to pain severity and frequency, and influenced by COMT gene variants.

Keywords:
chronic painfMRIfacial paingeneticsneuroimagingtemporomandibular disorders

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Pain Research

Background:

  • Chronic pain, such as temporomandibular disorder (TMD), involves complex brain alterations.
  • Brain signal variability analysis offers insights into pathological brain function.

Purpose of the Study:

  • To investigate alterations in blood-oxygen-level-dependent signal variability (BOLD_SV) in TMD patients.
  • To correlate BOLD_SV with clinical pain features and COMT Val158Met polymorphism.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) in 12 TMD patients and 24 healthy controls (HCs).
  • Measurement of BOLD_SV as the standard deviation of BOLD time series.
  • Correlation analysis with clinical pain assessments and COMT genotype.

Main Results:

  • TMD patients exhibited reduced BOLD_SV in the dorsolateral prefrontal cortex (dlPFC) across all frequency bands.
  • Specific alterations in the slow-3 band included reduced BOLD_SV in the thalamus, M1, S1, and heightened BOLD_SV in the temporal pole.
  • Lower BOLD_SV in sensorimotor regions correlated with higher pain intensity and sensitivity; lower BOLD_SV in PFC correlated with higher pain frequency.
  • COMT Val158Met polymorphism was associated with altered BOLD_SV in dlPFC and temporal pole.

Conclusions:

  • Chronic TMD is associated with aberrant BOLD_SV in brain circuits regulating pain modulation, sensation, and motor control.
  • BOLD_SV alterations in TMD patients correlate with pain severity and frequency.
  • COMT Val158Met polymorphism may influence TMD symptoms via its impact on brain signal variability involved in pain regulation.