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Updated: Nov 16, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Determinants of the Outcome of the Transition of Children with Sickle Cell Disease to Adult Programs
Samir K Ballas1, Gaye Riddick-Burden2, Elisabeth Congdon-Martin3
1Cardeza Foundation for Hematologic Research, Department of Medicine, Sidney Medical, Thomas Jefferson University, Philadelphia, PA, USA.
Abstract:
Transition of adolescents with sickle cell disease to adult programs is associated with increased morbidity and mortality. The reasons for this poor outcome are not well known. This report describes the various factors that affect the outcome of the transition process. These include four inter-personal factors: country of residence, region within the country of residence, the health care system and intra-personal factors. Each factor is described in some detail. Understanding these factors and the establishment of guidelines or recommendations could improve the outcome of this critical transition in the life of patients with sickle cell disease.
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