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Related Concept Videos

RNA-seq03:21

RNA-seq

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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DNA Helicases00:55

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DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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Related Experiment Video

Updated: Nov 16, 2025

Studying DNA Looping by Single-Molecule FRET
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Uncovering the Mechanical Code of DNA Using 'Loop-seq'.

Marek Marzec1

  • 1University of Silesia in Katowice, Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, Jagiellonska 28, 40-032 Katowice, Poland.

Trends in Genetics : TIG
|February 24, 2021
PubMed
Summary

Researchers developed a new method to measure DNA mechanics across the entire genome. This high-throughput tool allows for deeper investigation into DNA

Keywords:
DNA loopingDNA mechanicstightly bent DNA

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Area of Science:

  • Molecular Biology
  • Genomics
  • Biophysics

Background:

  • DNA mechanical properties are crucial for various biological processes.
  • Understanding these properties is key to deciphering cellular functions.

Purpose of the Study:

  • To describe a novel method for measuring DNA mechanics on a genome-wide scale.
  • To provide a high-throughput tool for studying DNA mechanical properties.

Main Methods:

  • Genome-scale measurement of DNA mechanics.
  • Development of a high-throughput assay for DNA mechanical property analysis.

Main Results:

  • A method to measure DNA mechanics at the genome scale has been established.
  • This technique offers high-throughput capabilities.

Conclusions:

  • The developed tool opens new avenues for investigating DNA mechanics.
  • This advancement facilitates research into the chromatin regulatory landscape.