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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
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Enterococcal Physiology and Antimicrobial Resistance: The Streetlight Just Got a Little Brighter

Louis B Rice1

  • 1Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA lrice@lifespan.org.

Mbio
|February 24, 2021
PubMed

Insights

Multiresistant Enterococcus faecalis strains possess unique physiology and resistance mechanisms. Functional genomics research explores the genetic basis of this antimicrobial resistance, identifying new avenues for study.

Area of Science:

  • Microbiology
  • Genomics
  • Antimicrobial Resistance

Background:

  • Enterococcus faecalis presents distinct physiology and antimicrobial susceptibility compared to other pathogens.
  • Multiresistant strains arise from intrinsic resistance and acquired determinants, influenced by environmental factors and genetic exchange.
  • Intrinsic resistance in E. faecalis is complex and linked to its fundamental physiology.

Purpose of the Study:

  • To investigate the genetic basis of Enterococcus faecalis physiology and antimicrobial resistance.
  • To explore the interplay between intrinsic and acquired resistance mechanisms in E. faecalis.
  • To identify novel research directions for understanding E. faecalis antimicrobial resistance.

Main Methods:

  • Utilized functional genomics approaches to study Enterococcus faecalis.
  • Analyzed genetic underpinnings of species physiology.
  • Examined determinants of antimicrobial resistance phenotypes.

Main Results:

  • Identified genetic factors contributing to Enterococcus faecalis physiology.
  • Explored mechanisms behind both intrinsic and acquired antimicrobial resistance.
  • Highlighted areas requiring further investigation into E. faecalis resistance.

Conclusions:

  • Functional genomics provides insights into Enterococcus faecalis physiology and resistance.
  • Further research is needed to fully elucidate the complex resistance mechanisms.
  • The study opens new avenues for exploring antimicrobial resistance in E. faecalis.
Keywords:
Enterococcusantimicrobial resistancecarbohydrate metabolismfunctional genomics

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