Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

3.7K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.7K
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

2.6K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
2.6K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

697
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
697
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

1.5K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.5K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

402
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
402
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

530
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
530

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seasonal variation of reproductive performance, foetal development and progesterone concentrations of sheep in the subtropics.

Reproduction in domestic animals = Zuchthygiene·2008
Same author

Validation of a soccer skill test for use with females.

International journal of sports medicine·2008
Same author

Assessment of the need to coat particle collection cups of the NGI to mitigate droplet bounce when evaluating nebuliser-produced droplets.

Pharmeuropa scientific notes·2008
Same author

Cooling the NGI - an approach to size a nebulised aerosol more accurately.

Pharmeuropa scientific notes·2008
Same author

Multiplex PCR for differential diagnosis of emerging typhoidal pathogens directly from blood samples.

Epidemiology and infection·2008
Same author

Gelrite microgels for sustained oral drug delivery-formulation and evaluation.

Current drug delivery·2008

Related Experiment Video

Updated: Nov 16, 2025

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.1K

Quantifying Worsened Glycemic Control During the COVID-19 Pandemic.

C J W Ledford1, C Roberts1, E Whisenant1

  • 1From the Department of Family Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD (CJWL); Department of Family Medicine, Augusta University, Augusta, GA (CR, EW, CW, KA, JB, AA, DAS).

Journal of the American Board of Family Medicine : JABFM
|February 24, 2021
PubMed
Summary

Glycemic control worsened during the COVID-19 pandemic. Hemoglobin A1c levels in May 2020 were significantly higher than in May 2019, indicating poorer diabetes management.

Keywords:
COVID-19Family MedicineHb A1cPandemicsPopulation HealthSocial Determinants of Health

More Related Videos

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

505
Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19
06:29

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19

Published on: May 25, 2022

2.6K

Related Experiment Videos

Last Updated: Nov 16, 2025

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.1K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

505
Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19
06:29

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19

Published on: May 25, 2022

2.6K

Area of Science:

  • Endocrinology
  • Public Health
  • Epidemiology

Background:

  • The COVID-19 pandemic significantly disrupted healthcare delivery and patient routines.
  • Glycemic control is crucial for managing diabetes and preventing long-term complications.
  • Understanding the pandemic's impact on chronic disease management is essential for public health strategies.

Purpose of the Study:

  • To evaluate changes in glycemic control (measured by HbA1c) in outpatients during the early COVID-19 pandemic compared to the previous year.
  • To quantify the difference in glycemic control between the two periods.
  • To investigate the association between social determinants of health and glycemic control variations.

Main Methods:

  • Retrospective analysis of electronic medical records from a family medicine clinic.
  • Inclusion of 300 patients with baseline HbA1c and results from May 2019 or May 2020.
  • Statistical comparison of Hemoglobin A1c levels between the two cohorts, controlling for demographic factors.

Main Results:

  • Mean baseline HbA1c levels were similar between the 2019 and 2020 groups.
  • Mean HbA1c decreased from baseline in May 2019 but increased in May 2020.
  • Adjusted mean HbA1c in May 2020 (7.73) was significantly higher than in May 2019 (7.16).

Conclusions:

  • Glycemic control significantly worsened in the patient population during the early COVID-19 pandemic compared to 2019.
  • The mean HbA1c difference was 0.57.
  • No significant associations were found between patient demographic variables, including race, and the observed changes in glycemic control.