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[Multiple meningiomas with Werner's syndrome--a case report]
S Mashiyama1, K Mizoi, A Takahashi
1Division of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.
No Shinkei Geka. Neurological Surgery
|January 1, 1988
Summary
This report details a rare case of multiple meningiomas in a patient with Werner's syndrome. Surgical removal was successful, highlighting a potential association between these conditions.
Area of Science:
- Neuro-oncology
- Genetics
- Gerontology
Background:
- Werner's syndrome (WS) is a rare autosomal recessive disorder characterized by premature aging.
- Meningiomas are typically benign tumors arising from the meninges.
- The co-occurrence of WS and meningioma is exceptionally rare, with limited documented cases.
Observation:
- A 45-year-old male patient presented with personality changes and right-sided motor weakness.
- Clinical examination revealed characteristic features of WS, including small stature and scleroderma-like skin changes.
- Diagnostic imaging confirmed the presence of multiple meningiomas.
Findings:
- The patient exhibited a diabetic glucose tolerance test pattern.
- Cerebral angiography and CT scans identified multiple meningiomas.
- Surgical intervention involving chemical embolization and subsequent removal of the meningiomas was successful.
Implications:
- This case underscores the importance of considering neoplastic risks, such as meningiomas, in patients diagnosed with Werner's syndrome.
- Further research may elucidate the potential underlying genetic or molecular mechanisms linking WS and meningioma development.
- Understanding this association can improve diagnostic and management strategies for individuals with WS.