Related Experiment Video
Updated: Nov 16, 2025

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
Pterostilbene inhibits gallbladder cancer progression by suppressing the PI3K/Akt pathway
Chenhao Tong1, Yali Wang1, Jiandong Li1
1Department of Hepatobiliary Surgery, Shaoxing Hospital, Zhejiang University School of Medicine (Shaoxing People's Hospital), No. 568 Zhongxing North Road, Shaoxing, 312000, Zhejiang, China.
Abstract:
Gallbladder cancer is the most common malignant tumor of the biliary system and is characterized by difficulty to diagnose in early stages, a high degree of malignancy, and poor prognosis. Finding new drugs may improve the prognosis for this dismal cancer. Herein, we investigated the potential application of pterostilbene (PTS) against gallbladder cancer in vivo and in vitro. PTS potently inhibited cell proliferation, migration and invasion of gallbladder cancer cells. Moreover, PTS also had a function of inducing apoptosis in vitro. Meanwhile, PTS reversed EMT with a correlated inhibition of PI3K/Akt activation. Tumor xenograft models showed that PTS inhibited tumor growth and had low toxicity in vivo, which were consistent with the in vitro data. These findings indicate that PTS arrests cell growth through inhibition of PI3K/AKT signaling and is a potential drug for the therapy of gallbladder cancer.
More Related Videos
Related Concept Videos
Drugs that Stabilize Microtubules
PI3K/mTOR/AKT Signaling Pathway
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Inhibition of Cdk Activity
Drugs that Destabilize Microtubules
Targeted Cancer Therapies
There are several types of targeted therapies against...

