NEBULIZED MAGNESIUM VERSUS KETAMINE FOR PREVENTION OF POST-OPERATIVE SORE THROAT IN PATIENTS FOR GENERAL ANAESTHESIA

Area of Science:

• Anesthesiology
• Pharmacology

Background:

• Post-operative sore throat is a frequent and distressing complication following general anesthesia.
• Current management strategies for sore throat are often inadequate.

Purpose of the Study:

• To compare the efficacy of nebulized Magnesium and Ketamine in reducing the incidence and severity of post-operative sore throat.
• To evaluate these effects at multiple time points up to 24 hours after extubation.

Main Methods:

• A randomized controlled trial involving 99 adult patients (ASA I-II, aged 16-65).
• Patients received pre-induction nebulized Ketamine (50 mg), Magnesium Sulphate (250 mg), or saline for ten minutes.
• Sore throat incidence and severity were assessed at 2, 4, 8, 12, and 24 hours post-extubation.

Main Results:

• Magnesium and Ketamine groups showed significantly lower sore throat incidence at 4, 8, 12, and 24 hours compared to the saline group (p < 0.05).
• Both Magnesium and Ketamine groups reported significantly less severe sore throat at 4 and 8 hours post-extubation (p < 0.05).

Conclusions:

• Pre-induction nebulization with Ketamine or Magnesium effectively decreases the incidence and severity of post-operative sore throat.
• These agents represent a promising therapeutic option for managing post-anesthesia sore throat.