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Updated: Nov 16, 2025

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
Oncogenic mechanisms in renal insufficiency
Simona Ruxandra Volovat1, Constantin Volovat1, Ingrith Miron1
1Department of Medical Oncology, University of Medicine and Pharmacy 'Grigore T Popa', Iasi, Romania.
Abstract:
The prevalence of both cancer and end-stage renal disease is increasing. In addition, medical advances have meant increased survival rates for both diseases. Many chemotherapeutics are renally excreted, and conversely, renal insufficiency promotes a pro-neoplastic state, including genitourinary and other cancers. Dialysis prolongs life while increasing cancer risk. Proposed oncogenic mechanisms include immune dysfunction, chronic inflammation, changes in gut microbiota and stimulation of the renin-angiotensin system. This review summarizes current concepts in the relationship between cancer and renal insufficiency.
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