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Correlation of Dietary Intake and Helicobacter pylori Infection with Multiple Sclerosis, a Case-Control Study in
Sara Kiani1,2, Alireza Vakilian, Zahra Kamiab1,3
1Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Background:
Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system. Some environmental factors, such as Helicobacter pylori infection (HPI), are likely to be considered a protective factor in MS. Dietary intake may provide exposure to or have protective effects for MS. The present study aimed to determine the relationship between serum anti-H. pylori IgG antibody (HPIA) level and dietary intake in patients with MS referred to the MS Clinic in Rafsanjan city, Iran.
Methods:
The present case-control study was conducted on 97 patients with MS and 95 controls. The two groups had no significant difference in age and gender (p > 0.05). HPIA was checked, and the food frequency questionnaire was completed in both groups to measure nutritional intake. All data were analyzed by the SPSS 20 software using independent t-test, Chi-Square, Mann-Whitney U test, and correlation.
Results:
The median serum HPIA level was significantly lower in MS cases than in controls. Furthermore, the median consumption of glutamic acid, arginine, serine, aspartic acid, alanine, proline, and caffeine was significantly lower in MS cases than in controls. A significant positive correlation was found between the levels of linoleic acid, lactose, Ca, molybdenum, galactose, leucine, and valine, and the level of HPIA in controls.
Conclusion:
Our study results demonstrated that some dietary nutrients had correlations with MS and HPI. Therefore, professionals from multiple disciplines must find which foods contain these dietary nutrients in future studies.
Insights
This study found lower levels of antibodies to Helicobacter pylori infection (HPI) and certain dietary nutrients in multiple sclerosis (MS) patients. These findings suggest a link between diet, HPI, and MS risk.
Area of Science:
- Neuroimmunology
- Nutritional Science
- Microbiome Research
Background:
- Multiple sclerosis (MS) is a central nervous system autoimmune disease.
- Environmental factors, including Helicobacter pylori infection (HPI), may influence MS risk.
- Dietary intake is a potential modifiable factor in MS.
Purpose of the Study:
- To investigate the association between serum anti-H. pylori IgG antibody (HPIA) levels and dietary intake in Iranian MS patients.
- To compare HPIA levels and nutritional intake between MS patients and healthy controls.
Main Methods:
- A case-control study involving 97 MS patients and 95 controls.
- Measurement of serum HPIA levels and assessment of dietary intake using a food frequency questionnaire.
- Statistical analysis including t-tests, Chi-square, Mann-Whitney U test, and correlation analysis.
Main Results:
- MS patients exhibited significantly lower median serum HPIA levels compared to controls.
- Reduced median consumption of specific amino acids (glutamic acid, arginine, serine, aspartic acid, alanine, proline) and caffeine was observed in MS patients.
- Positive correlations between HPIA levels and intake of linoleic acid, lactose, calcium, molybdenum, galactose, leucine, and valine were identified in controls.
Conclusions:
- Dietary nutrients show correlations with both MS and HPI.
- Further interdisciplinary research is needed to identify specific foods containing these associated nutrients.
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